Ulcer Disease Information Center

Electron micrograph of H. pylori

General Information Information from sources such as the National Institute of Diabetes and Digestive and Kidney Diseases, Centers for Disease Control, etc. Articles An archive of articles from publications such as H Pylori News, Medical Sciences Bulletin, and PNN Pharmacotherapy Line. Research News from Medical Meetings Drugs Used in the Treatment of Ulcers Links to entries in DrugDB, our acclaimed database of information about specific drugs. Other Sources of Information Links to Web sites and other resources for ulcer disease information. Access Peptic ulcer resources for patients on Mediconsult.com, including News, Educational Materials, and Patient Support Forum.

Peptic Ulcer FAQs

Comprehensive frequently-asked questions and answers from the National Institute of Diabetes and Digestive and Kidney Diseases.

The following articles were first published on PharmInfoNet between May 96 through July 97.
• Tufts University Diet and Nutrition Letter - Special Report
• The bacteria behind ulcers.
• The treatment of Helicobacter pylori infection in the management of peptic ulcer disease.
• Helicobacter pylori: the etiologic agent for peptic ulcer.
• Breathtaking technology for the detection of Helicobacter pylori.
• Reproducibility of the 14C urea breath test repeated after 1 week.
• Trefoil peptides: A novel modality to prevent gastric injury?
• Helicobacter pylori may induce bile reflux: link between H pylori and bile induced injury to gastric epithelium.
• Helicobacter pylori increases proliferation of gastric epithelial cells.
• Specialists back antibiotic use to cure ulcers. Wall Street Journal
• Diagnosing dyspepsia: Any controversies left?
• Polio and small pox: diseases of historical interest because of vaccines. Will this also apply to Helicobacter pylori?
• How good are the new heartburn drugs?
• Absence of dyspeptic symptoms as a test for Helicobacter pylori eradication.
• Initial endoscopy or empirical therapy with or without testing for Helicobacter pylori for dyspepsia: A decision analysis.
• Medical treatment of peptic ulcer disease.
• Effect of administration of ranitidine bismuth citrate with food on the suppression and eradication of Helicobacter pylori in infected volunteers.
• More heartburn relief on the way promises to unsettle market.
• Cure of Helicobacter pylori infection: Role of duration of treatment with omeprazole and amoxicillin.
• Progression of gastritis to monoclonal B-cell lymphoma with resolution and recurrence following eradication of Helicobacter pylori.
• Management of Helicobacter pylori infection in ulcer disease.
• Long-term follow-up of Helicobacter pylori serology after successful eradication.
• New treatment for ulcers--and other stomach pains.
• Pathogenesis of gastric metaplasia of the human duodenum: role of Helicobacter pylori, gastric acid, and ulceration.
• Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids.
• Extract of Helicobacter pylori induces neutrophils to injure endothelial cells and contains antielastase activity.
• Triple therapy vs amoxicillin plus omeprazole for treatment of Helicobacter pylori infection: A multicenter, prospective, randomized, controlled study of efficacy and side effects.
• Effect of curing Helicobacter pylori infection on intragastric pH during treatment with omeprazole.
• Non-ulcer dyspepsia and peptic ulcer: the distribution in a population and their relation to risk factors (the Sorreisa gastro-intestinal disorder study).
• Role of Helicobacter pylori in ulcer healing and recurrence of gastric and duodenal ulcers in long-term NSAID users. Response to omeprazole dual therapy.
• Helicobacter pylori and perturbations in acid secretion: the end of the beginning.
• Gastric metaplasia and duodenal ulcer disease in children infected by Helicobacter pylori.
• Atrophic gastritis and Helicobacter Pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication.
• A mechanism by which Helicobacter pylori infection of the antrum contributes to the development of duodenal ulcer.
• Vitamin E concentrations in the human stomach and duodenum -- correlation with Helicobacter pylori infection.
• New drugs give doctors heartburn.
• Long-term course and consequences of Helicobacter pylori gastritis: Results of a 32-year follow-up study.
• Circulating anti-Helicobacter pylori immunoglobulin A antibodies and low serum pepsinogen I level are associated with increased risk of gastric cancer.
• Prevalence of metronidazole resistant Helicobacter pylori strains among Chinese peptic ulcer disease patients and normal controls in Hong Kong.
• Is saliva serology useful for the diagnosis of Helicobacter pylori?
• The risk of stomach cancer in patients with gastric or duodenal ulcers.
• Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin
• Consum Rep Health (Brief consumer item)
• Induction of gastric epithelial apoptosis by Helicobacter pylori
• P&G aims to win big in health care with tight focus.
• Could Helicobacter pylori infection increase of risk of coronary heart disease by modifying serum lipid concentrations?
• Helicobacter pylori in the stomach -- -a paradox unmasked.
• 4-day lansoprazole quadruple therapy: a highly effective cure for Helicobacter pylori infection.
• Tritec and Helidac approved for Helicobacter pylori peptic ulcer disease
• Drugstore aisle.
• Helicobacter pylori infection in children: relation with current household living conditions.
• Atrophic gastritis and Helicobacter pylori in reflux esophagitis.
• B-cell clonality and infection with Helicobacter pylori: implications for development of gastric lymphoma.
• Heterogeneous Helicobacter pylori isolates from members of a family with a history of peptic ulcer disease.
• Metronidzole-resistant H. pylori -- of questionable clinical importance.
• Heterogeneity in susceptibility to metronidazole among Helicobacter pylori isoaltes from patients with gastritis or peptic ulcer disease.
• Helicobacter heilmannii (formerly Gastrospirillum): association with pig and human gastric pathology.
• Practice guidelines for treatment of peptic ulcer disease.
• Helicobacter pylori infection in day care centers.
• Oral cavity as permanent reservoir of H. pylori (HP) and potential source of gastric reinfection.
• Companies target H. pylori infection with a broad range of diagnostic assay products.
• Helicobacter pylori and peptic ulcer diseases.
• Helicobacter pylori and mucosa-associated lymphoid tissue lymphoma.
• Relation between gastric acid output, Helicobacter pylori, and gastric metaplasia in the duodenal bulb.
• The role of Helicobacter pylori in pathogenesis: the spectrum of clinical outcomes.
• Helicobacter pylori eradication: Therapy other than with bismuth or proton-pump inhibitors.
• Helicobacter pylori, gastric acid, and duodenal gastric metaplasia.
• Breath test for Helicobacter pylori collection kit approved.
• Circadian gastric acidity in Helicobacter pylori positive ulcer patients with and without gastric metaplasia in the duodenum.
• Helicobacter pylori infection and gastroduodenal ulcer in self-defense officials in Japan.
• Cost-benefit analysis of testing for Helicobacter pylori in dyspeptic subjects.
• Prospects for the development of a vaccine against Helicobacter pylori.
• Evaluation of whole blood antibody kit to detect active Helicobacter pylori infection.
• Omeprazole vs two different doses of lansoprazole in triple therapy on H. pylori positive duodenal ulcer.
• The ten greatest medical advances in 1996.
• Helicobacter pylori and gastric cancer: An overrated risk?
• Two-day versus one-week anti-Helicobacter therapy in controlled bleeding ulcers: A prospective randomized trial.
• A quantitative analysis of symptoms of non-ulcer dyspepsia as related to age, pathology, and Helicobacter infection.
• Genetic diversity of Helicobacter pylori.
• Helicobacter pylori infection in Eastern Europe: Seroprevalence in the Polish population of Lower Silesia.
• Pooled analysis of anti-Helicobacter pylori treatment regimens.
• Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line.
• Randomised double blind controlled study of recurrence of gastric ulcer after treatment for eradication of Helicobacter pylori.
• The growth of primary low-grade B-cell gastric lymphoma is sustained by Helicobacter pylori.
• Does smoking predispose to peptic ulcer relapse after eradication of Helicobacter pylori?
• Helicobacter pylori infection.
• Highly effective twice-daily triple therapies for Helicobacter pylori infection and peptic ulcer disease: does in vitro metronidazole resistance have any clinical relevance?
• Evaluation of Helicobacter pylori in reflux esophagitis and Barrett's esophagus
• The Pyloritek Test and the CLO Test: accuracy and incremental cost analysis.
• Risk of infection with Helicobacter pylori and hepatitis A virus in different groups of hospital workers.
• Effect of eradication of Helicobacter pylori in patients with fundic atrophic gastritis.
• Usefulness of the 14C urea breath test as a semi-quantitative monitoring instrument after therapy for Helicobacter pylori infection.
• Lansoprazole and ranitidine affect the accuracy of the 14C- urea breath test by a pH-dependent mechanism..
• Gastric mucosa during treatment with lansoprazole: Helicobacter pylori is a risk factor for argyrophil cell hyperplasia.
• Anti-Helicobacter pylori treatment in bleeding ulcers: randomized controlled trial comparing 2-day versus 7-day bismuth quadruple therapy.
• Do ulcers burn out or burn on? Managing duodenal ulcer diathesis in the Helicobacter pylori era.
• Helicobacter pylori infection and coagulation in healthy people.
• Induction of acute gastritis and epithelial apoptosis by Helicobacter pylori lipopolysaccharide
• Therapy for bleeding peptic ulcers.
• Prospective study of Helicobacter pylori seropositivity and cardiovascular diseases in a general elderly population.
• Helicobacter pylori and iron deficiency.
• Pervasive occult gastrointestinal bleeding in an Alaska Native population with prevalent iron deficiency.

Med-Brief

• Gastric ulcer risk in users of Fosamax and NSAIDs - Oct 99
• Heartburn drug interferes with metabolism of alcohol - Jan 00

PNN Pharmacotherapy Line

• Antibiotics Alone Cure Duodenal Ulcers - Aug 97
• Antibiotics Not Linked to H. pylori Infections - Dec 97
• CDC, APhA Inaugurate Ulcer Awareness Week - Sep 99
• H. pylori Cure Associated with Reflux Esophagitis - Jun 97
• H. pylori in Gastric Ulcers: Tough Bugs - Mar 97
• H. pylori Link to Heart Disease Questioned in BMJ - Apr 98
• H. pylori Linked to Enteric Infection in Childhood - Apr 98
• H. pylori: Progress Toward a Vaccine - May 99
• Omeprazole: Role in Treatment of H. pylori - Mar 99
• Research Progressing Fast on Subtyping of H. pylori - Jul 97
• Triple Drug [therapy for H. pylori eradication] Allergy? - May 97

• Clarithromycin/omeprazole combo approved for H pylori ulcers - Jun 96
• Focus On... Antibiotics for Common Infections
• Focus On. . . Helicobacter pylori and Ulcers - Jun 96
• Focus On... Peptic Ulcer Disease
• Lansoprazole Against Gastric Acid - Jul 95
• Meretek's Helicobacter pylori Breath Test Approved - Jan 97
• OTC Famotidine for Acid Control
• Tritec and Helidac Approved for H. pylori Peptic Ulcer Disease - Sep 96

Research News from Medical Meetings

ACG95 EHLB: ACG Distinguished Lecture. Peptic Ulcer Disease: The Rest of the Story

ACG96 EHLB: The Baker Presidential Lecture "Helicobacter pylori in the Year 2000"

ACG96 EHLB: Does initial choice of Helicobacter pylori treatment regimen influence the recurrence rate of duodenal ulcer (DU)? A meta analysis

ACG97 EHLB: Presence of Helicobacter pylori in the Stomach Does Not Appear to Portend Risk of Significant Damage to the Esophagus

ACG97 EHLB: New Study Finds Cats Do Not Transmit Ulcer Bacteria to Humans

DDW96 EHLB: Does the Eradication of H. Pylori Prevent NSAID-Induced Ulcers

DDW96 EHLB: Is Helicobacter pylori infection a risk factor for gastric cancer in patients younger that 55 years of age?

DDW96 EHLB: Quadruple therapy in Helicobacter pylori eradication using omeprazole, sucralfate, tetracycline and metronidazole

DDW96 EHLB: Should Helicobacter Pylori Status be Determined Before Initiating Eradication Therapy in Patients With Chronic Duodenal Ulcer Disease?

DDW96 EHLB: A meta-analysis comparing endoscopic injection therapy and thermal methods in the treatment of hemorrhage caused by peptic ulcer

Drugs for Treating Ulcers and its Complications

• amoxicillin (Augmentin, Amoxil, Trimox)
• bismuth subsalicylate (PeptoBismol)
• bismuth subsalicylate plus tetracycline and metronidazole (Helidac)
• cimetidine (Tagamet HB)
• clarithromycin (Biaxin)
• famotidine (Pepcid AC)
• ibuprofen
• lansoprazole (Prevacid)
• metronidazole (Flagyl)
• misoprostol (Cytotec)
• nizatidine (Axid)
• omeprazole (Prilosec)
• ranitidine (Zantac 75)
• ranitidine bismuth citrate (Tritec)
• sucralfate (Carafate)
• tetracycline (Achromycin, Sumycin)

Options for the Treatment of H. pylori

Treatment options ranging from the cheapest, fastest, newest to homeopathic.

Helicobacter Pylori in Peptic Ulcer Diseases

National Library of Medicine, NIH consensus statement (1994).

Helicobacter Pylori Quiz

University of Chicago Health Services (US)

Helicobacter Pylori Foundation

Last modified on . © 1999 Mediconsult.com, Limited. All rights reserved. As seen on PharmInfoNet ()

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